Schedule

09:30 - 10:00 Registration and Coffee

10.00 - 10.10 Welcome by organizing committee

10.10 – 12.00 Theme 1: Design

10.15 – 11.00 Jason Zhang (UCLA) AI Designed proteins for Cell Biology

11.00 – 12.00 Short talks

11.00 - 11.20 Perri Humpreys (UU) - Purification-free single-molecule dissection of multidomain protein folding

11.20 - 11.40 Dane Marijan (Leiden University) - Nanoscopic characterization of chaperone-mediated processing of a-syn amyloid fibers

11.40 – 12.00 Elise Camilleri (RUG) - Unravelling Chaperone Function on the Single-Molecule Level

12.00 – 14.00 Lunch and poster session

14.00 - 15.15 Theme 2: Function

14.00 - 14.40 Ilana Berlin (Leiden UMC) - Chemogenetic Ubiquitin E1 Inhibitor TAK-243 CRISPR Screen Uncovers HAPSTR1/HUWE1 Axis in Chromatin Proteostasis and Cell Cycle Control

14.40 – 15.20 Short talks

14.40 – 15.00 Dijm de Ridder (Leiden University) - Requirements of HSPA8-mediated amyloid disaggregation

15.00 -15.20 Danny Schildknegt (UU) - Cnpy5 action and interacting proteins

15.20 – 15.40 Coffee break

15.40 – 17.00 Theme 3: Dysregulation

15.40 – 16.30 Susanne Wegmann (DZNE Berlin) - How do neuronal cells keep Tau in control? - A balance between solubility, self-association, and aggregation

16.30 - 17.10 Short talks

16.30-16.50 Maiara Kolbe Musskopf (UMCG) - DNAJB6 protects FG-Nups in gel-like assemblies driven by its conserved intrinsically disordered region

16.50-17.10 Vera van Schijndel (Utrecht University) - Polyglutamine aggregation occurs by stochastic nucleation in Caenorhabditis elegans neurons

17.10 Closing remarks and Drinks & Bites